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- Title
The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [<sup>11</sup>C]UCB-J.
- Authors
Toyonaga, Takuya; Khattar, Nikkita; Wu, Yanjun; Lu, Yihuan; Naganawa, Mika; Gallezot, Jean-Dominique; Matuskey, David; Mecca, Adam P.; Pittman, Brian; Dias, Mark; Nabulsi, Nabeel B.; Finnema, Sjoerd J.; Chen, Ming-Kai; Arnsten, Amy; Radhakrishnan, Rajiv; Skosnik, Patrick D.; D'Souza, Deepak Cyril; Esterlis, Irina; Huang, Yiyun; van Dyck, Christopher H.
- Abstract
Purpose: Aging is a major societal concern due to age-related functional losses. Synapses are crucial components of neural circuits, and synaptic density could be a sensitive biomarker to evaluate brain function. [11C]UCB-J is a positron emission tomography (PET) ligand targeting synaptic vesicle glycoprotein 2A (SV2A), which can be used to evaluate brain synaptic density in vivo. Methods: We evaluated age-related changes in gray matter synaptic density, volume, and blood flow using [11C]UCB-J PET and magnetic resonance imaging (MRI) in a wide age range of 80 cognitive normal subjects (21–83 years old). Partial volume correction was applied to the PET data. Results: Significant age-related decreases were found in 13, two, and nine brain regions for volume, synaptic density, and blood flow, respectively. The prefrontal cortex showed the largest volume decline (4.9% reduction per decade: RPD), while the synaptic density loss was largest in the caudate (3.6% RPD) and medial occipital cortex (3.4% RPD). The reductions in caudate are consistent with previous SV2A PET studies and likely reflect that caudate is the site of nerve terminals for multiple major tracts that undergo substantial age-related neurodegeneration. There was a non-significant negative relationship between volume and synaptic density reductions in 16 gray matter regions. Conclusion: MRI and [11]C-UCB-J PET showed age-related decreases of gray matter volume, synaptic density, and blood flow; however, the regional patterns of the reductions in volume and SV2A binding were different. Those patterns suggest that MR-based measures of GM volume may not be directly representative of synaptic density.
- Subjects
VOXEL-based morphometry; GRAY matter (Nerve tissue); POSITRON emission tomography; NEURAL circuitry; MAGNETIC resonance imaging; SYNAPTIC vesicles; NERVE endings
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2024, Vol 51, Issue 4, p1012
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-023-06487-8