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- Title
Ceftaroline pharmacodynamic activity versus community-associated and healthcare-associated methicillin-resistant Staphylococcus aureus, heteroresistant vancomycin-intermediate S. aureus, vancomycin-intermediate S. aureus and vancomycin-resistant S. ...
- Authors
Zhanel, George G.; Rossnagel, Emma; Nichol, Kim; Cox, Lauren; Karlowsky, James A.; Zelenitsky, Sheryl; Noreddin, Ayman M.; Hoban, Daryl J.
- Abstract
Background This study assessed the pharmacodynamics of ceftaroline against methicillin-resistant Staphylococcus aureus (MRSA), heteroresistant (h) vancomycin-intermediate S. aureus (hVISA), VISA and vancomycin-resistant S. aureus (VRSA) using an in vitro model. Methods Two methicillin-susceptible S. aureus (MSSA), one community-associated (CA)-MRSA, one healthcare-associated (HA)-MRSA, one hVISA, three VISA and two VRSA were studied. The pharmacodynamic model was inoculated with a concentration of 1 × 106 cfu/mL and ceftaroline dosed every 12 h (at 0 and 12 h) to simulate the ƒCmax and t1/2 obtained after administering 600 mg intravenously every 12 h (ƒCmax, 16 mg/L; t1/2, 2.6 h). Samples were collected over 24 h to assess viable growth and changes in ceftaroline MIC over time. Results Ceftaroline ƒT>MIC of ≥92% (ceftaroline MICs, ≤1 mg/L) was bactericidal (≥3 log10 killing) against MSSA, CA-MRSA, HA-MRSA, hVISA, VISA and VRSA at 12 and 24 h. No bacterial regrowth occurred over the study period and no change in ceftaroline MIC was observed. Conclusions Ceftaroline ƒT>MIC of ≥92% (ceftaroline MICs, ≤1 mg/L) was bactericidal (≥3 log10 killing) against MSSA, CA-MRSA, HA-MRSA, hVISA, VISA and VRSA at 12 and 24 h.
- Subjects
METHICILLIN-resistant staphylococcus aureus; VANCOMYCIN; VANCOMYCIN resistance; PHARMACODYNAMICS; BACTERIA
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2011, Vol 66, Issue 6, p1301
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkr110