We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Periplasmic adaptor protein AcrA has a distinct role in the antibiotic resistance and virulence of Salmonella enterica serovar Typhimurium.
- Authors
Blair, Jessica M. A.; La Ragione, Roberto M.; Woodward, Martin J.; Piddock, Laura J. V.
- Abstract
Objectives: AcrA can function as the periplasmic adaptor protein (PAP) in several RND tripartite efflux pumps, of which AcrAB-TolC is considered the most important. This system confers innate multiple antibiotic resistance. Disruption of acrB or tolC impairs the ability of Salmonella Typhimurium to colonize and persist in the host. The aim of this study was to investigate the role of AcrA alone in multidrug resistance and pathogenicity.
- Subjects
PROTEINS; ANTIBIOTICS; DRUG resistance; SALMONELLA; SALMONELLA typhimurium; PATHOGENIC microorganisms
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2009, Vol 64, Issue 5, p965
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkp311