We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Hypertension, Diabetes Type II, and Their Association: Role of Arterial Stiffness.
- Authors
Smulyan, Harold; Lieber, Ari; Safar, Michel E.
- Abstract
In patients with both hypertension and type II diabetes, the systolic blood pressure (SBP) increases linearly with age, while that of diastolic blood pressure (DBP) declines curvilinearly as early as age 45, all suggesting the development of increased arterial stiffness. Increased stiffness is an important, independent, and significant risk predictor in subjects with hypertension and diabetes. In patients with both diseases, stiffness assessed at the same mean arterial pressure (MAP) was significantly higher in diabetic patients. Arterial stiffness is related to age, heart rate (HR), and MAP, but in diabetic patients, it also related to diabetes duration and insulin treatment (IT). In the metabolic syndrome (MetSyn), diabetes also acts on the small arteries through capillary rarefaction to reduce the effective length of the arterial tree, increases the reflected pulse wave and thus the pulse pressure (PP). These studies indicate that diabetes and hypertension additively contribute to increased pulsatility and suggest that any means to reduce stiffness would be beneficial in these conditions.
- Subjects
PATIENTS; HYPERTENSION; PEOPLE with diabetes; DISEASE risk factors; ARTERIAL diseases; SYSTOLIC blood pressure
- Publication
American Journal of Hypertension, 2016, Vol 29, Issue 1, p5
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpv107