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- Title
a genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins
- Authors
Ranade, Koustubh; Hinds, David; Hsiung, Chao Agnes; Chuang, Lee-Ming; Chang, Mau-Song; Chen, Ying-Tsung; Pesich, Robert; Hebert, Joan; Chen, Yii-Der I.; Dzau, Victor; Olshen, Richard; Curb, David; Botstein, David; Cox, David R.; Risch, Neil
- Abstract
: BackgroundOur understanding of genes that predispose to essential hypertension is poor.: MethodsA genome-wide scan for linkage at ∼10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low–normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).: ResultsThere was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.: ConclusionsWe can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.
- Subjects
HYPERTENSION; GENETICS
- Publication
American Journal of Hypertension, 2003, Vol 16, Issue 2, p158
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(02)03245-4