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- Title
Plasminogen Activator Inhibitor-1 and Angiotensin I Converting Enzyme Gene Polymorphism in Patients With Hypertension<sup>*</sup>.
- Authors
Jeng, Jing-Ren; Harn, Horng-Jyh; Yueh, Kuo-Cheu; Jeng, Chii-Yuan; Shieh, Shyh-Ming
- Abstract
Deletion polymorphism of angiotensin I-converting enzyme (ACE) gene has been reported to be an independent risk factor for myocardial infarction. Plasminogen activator inhibitor-1 (PAI-1) was proposed to be a link between the renin-angiotensin system and thrombotic risk. This study was undertaken to investigate the possible association between the insertion/deletion (I/D) polymorphism of the ACE gene and plasma PAI-1 levels in 160 patients with mild-to-moderate hypertension. The I/D genotypes were determined by polymerase chain reaction with oligonucleotide primers flanking the polymorphic region in intron 16 of the ACE gene. Baseline levels of PAI-1 antigen and activity and tissue plasminogen activator (t-PA) antigen were determined in fasting morning plasma samples. It was found that patients with homozygote deletion (DD, n = 37) ACE genotype did not have significantly higher plasma levels of PAI-1 antigen (31.2 ± 15.6 ng/mL v 28.4 ± 15.1 ng/mL or 27.2 ± 13.2 ng/mL, P = .42), PAI-1 activity (16.2 ± 10.6 IU/mL v 14.1 ± 9.4 IU/mL or 15.0 ± 9.9 IU/mL, P = .60), or t-PA antigen (14.6 ± 6.0 ng/mL v 13.4 ± 4.9 ng/mL or 14.6 ± 5.7 ng/mL, P = .40) as compared to those with heterozygote (DI, n = 67) or homozygote insertion (II, n = 56) genotypes. On multiple regression analysis, the ACE genotypes did not appear to be significant predictors for plasma PAI-1 levels and t-PA antigen after adjustment with age, sex, body mass index, plasma triglyceride, cholesterol, and glucose. In conclusion, the results indicated that the I/D polymorphism of the ACE gene was not related to plasma PAI-1 levels in a Chinese population with hypertension. The ACE genotypes may not have a role in influencing the fibrinolysis in hypertension.Am J Hypertens (1998) 11, 235-239; doi: S0895-7061(97)00476-7
- Publication
American Journal of Hypertension, 1998, Vol 11, Issue 2, p235
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(97)00476-7