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- Title
Novel events in the molecular regulation of muscle mass in critically ill patients.
- Authors
Constantin, Despina; McCullough, Justine; Mahajan, Ravi P.; Greenhaff, Paul L.
- Abstract
Non-technical summary A clinical trait of critically ill patients following trauma, surgical complications and/or sepsis is the presence of a marked skeletal muscle wasting, which severely compromises muscle function, especially the respiratory muscles, and clinical outcomes such as morbis, mortality and the length of hospitalization. However, the molecular mechanisms responsible for this are largely unresolved. In this paper we provide novel and interesting translational data that show how the muscle mass is regulated during critical illness. The present observations also show that the muscle signalling pathways are not only important for the size of muscle mass, but could also play a significant role in the whole body glucose control. This is extremely important and relevant to the clinical setting as uncontrolled blood glucose concentrations in critically ill patients impact on clinical outcome. From a clinical perspective, the present data suggest therapeutic strategies to preserve muscle mass and metabolic function in critical illness.
- Subjects
SURGICAL complications; SEPSIS; HOSPITAL care; MUSCULOSKELETAL system injuries; GLUCOSE
- Publication
Journal of Physiology, 2011, Vol 589, Issue 15, p3883
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2011.206193