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- Title
2B synaptic or extrasynaptic determines signalling from the NMDA receptor.
- Authors
Hardingham, Giles E.
- Abstract
Discusses research being done on the role of synaptic N-methyl-D-aspartate receptor (NMDAR) in NMDAR signaling to extracellular regulated kinases (ERK). Referece to a study by A. Ivanov, C. Pellegrino et al., published in the 2006 issue of the "Journal of Physiology"; Effect of calcium channel increases on synaptic NMDAR-dependent activation of ERK; Actions of NMDAR in cAMP response element-binding gene expression; Relevance of extrasynaptic NMDAR to the pathophysiology of hypoxia and ischemia.
- Subjects
METHYL aspartate; CELL receptors; PROTEIN kinases; CALCIUM channels; GENE expression
- Publication
Journal of Physiology, 2006, Vol 572, Issue 3, p614
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2006.109603