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- Title
Pearls and pitfalls in experimental in vivo models of headache: Conscious behavioral research.
- Authors
Romero-Reyes, Marcela; Ye, Yi
- Abstract
Background: Physiological studies have been determinant for the understanding of migraine pathophysiology and thescreening of novel therapeutics. At present, there is no animal model that translates fully the clinical symptoms ofmigraine, and generally these studies are conducted on anesthetized animals.Methodology: Pain as well as non-painful symptoms such as photophobia, need to have a conscious individual to beexperienced; therefore, the new development and adaptation of behavioral assays assessing pain and other non-painfulsymptomatology in conscious animals represents a great opportunity for headache research and it is exciting that moreand more researchers are using behavioral paradigms.Summary: This review will describe the different behavioral models for the study of headache that are performed innon-anesthetized conscious animals. The pearls and challenges for measuring hypersensitivity in rodents such as thecommon tests for measuring mechanical allodynia and thermal hyperalgesia have been the landmark for the developmentof assays that measure hypersensitivity in the craniofacial region. Here we describe the different behavioral assays thatmeasure hypersensitivity in the craniofacial region as well as the established behavioral models of trigeminovascularnociception and non-nociceptive migrainous symptoms.
- Subjects
HEADACHE; MIGRAINE; LABORATORY rodents; HYPERALGESIA; CLUSTER headache
- Publication
Cephalalgia, 2013, Vol 33, Issue 8, p566
- ISSN
0333-1024
- Publication type
Article
- DOI
10.1177/0333102412472557