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- Title
Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis.
- Authors
Andreasen, Laura; Bertelsen, Litten; Ghouse, Jonas; Lundegaard, Pia R.; Ahlberg, Gustav; Refsgaard, Lena; Rasmussen, Torsten B.; Eiskjær, Hans; Haunsø, Stig; Vejlstrup, Niels; Svendsen, Jesper H.; Olesen, Morten S.
- Abstract
Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 ± 4 vs 64 ± 5%, P < 0.001). We obtained similar findings in early-onset AF patients without TTNtv compared with controls (61 ± 4 vs 64 ± 5%, P = 0.02). We furthermore found a statistically significant increase in LA LGE when comparing early-onset AF TTNtv cases with controls. Using state-of-the-art CMR, we found that early-onset AF patients, irrespective of TTNtv carrier status, had reduced LVEF, indicating that early-onset AF might not be as benign as previously thought.
- Subjects
ATRIAL fibrillation; HEART diseases; CONNECTIN; VENTRICULAR ejection fraction; CARDIAC magnetic resonance imaging
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-66671-w