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- Title
Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review.
- Authors
Faur, Alexandra Corina; Gurban, Camelia Vidiţa; Dăescu, Ecaterina; Tîrziu, Răzvan Vlad; Lazăr, Daniela Cornelia; Ghenciu, Laura Andreea
- Abstract
Breast cancer stands as the primary cause of cancer-related mortality among women worldwide, often presenting with distant metastases upon diagnosis. Ovarian metastases originating from breast cancer represent a range of 3–30% of all ovarian neoplasms. Case Report: Herein, we present the histopathological, histochemical, and immunohistochemical findings of a rare case involving mucin-producing lobular breast carcinoma metastasizing to an ovarian fibroma in an 82-year-old female previously diagnosed with lobular breast carcinoma. Histopathological examination of the excised tissues revealed a biphasic neoplasm characterized by tumor cells expressing AE-1/AE-3 cytokeratin, mammaglobin, GCDFP-15, inhibin, and calretinin. Positive mucin staining was observed using histochemical techniques, and reticulin fibers were demonstrated using the Gordon–Sweets technique. A final diagnosis of mucin-producing lobular breast carcinoma metastatic to a benign ovarian fibroma was rendered. Conclusion: The occurrence of metastatic breast carcinoma overlaid on an ovarian tumor represents a rare and diagnostically challenging scenario.
- Subjects
LOBULAR carcinoma; LITERATURE reviews; IMMUNOHISTOCHEMISTRY; FIBROMAS; HISTOPATHOLOGY; OVARIAN tumors
- Publication
Diagnostics (2075-4418), 2024, Vol 14, Issue 9, p953
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics14090953