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- Title
Colonic Mucosal Interleukin 1 Receptor Antagonist in Inflammatory Bowel Disease.
- Authors
Nishiyama, Tsutomu; Mitsuyama, Keiichi; Toyonaga, Atsushi; Sasaki, Ei; Tanikawa, Kyuichi
- Abstract
To clarify the role of the interleukin 1 receptor antagonist (IL-lra) in patients with inflammatory bowel disease (IBD), we assessed the local IL-lra concentrations in tissue homogenates using a specific enzyme-linked immunosorbent assay and examined the immunohistochemical localization using a monoclonal antibody against IL-lra. In patients with IBD, regardless of the disease activity, the mucosal concentration of IL-lra in affected areas was elevated, and the concentration during the active phase was comparable to that measured during the inactive phase. In contrast, the IL-1β tissue concentration was higher during the active than during the inactive phase. The IL-1 ra/IL-1β tissue concentration ratio in the affected areas was decreased in patients with active IBD as compared with normal controls or patients with other types of colitis. Immunohistochemical studies identified lamina propria mononuclear cells, especially macrophages, as the major source of IL-1 ra in IBD tissue. Our results suggest that IL-1 ra plays a pivotal role in regulating inflammation in IBD. Copyright © 1994 S. Karger AG, Basel
- Publication
Digestion, 1994, Vol 55, Issue 6, p368
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000201167