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- Title
Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging.
- Authors
Yuan Li; Adeniji, Nia T.; Weiguo Fan; Koshi Kunimoto; Török, Natalie J.
- Abstract
Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH) have emerged as the leading causes of chronic liver disease-related mortality. The prevalence of NAFLD/NASH is expected to increase given the epidemics of obesity and type 2 diabetes mellitus. Older patients are disproportionally affected by NASH and related complications such as progressive fibrosis, cirrhosis and hepatocellular carcinoma; however, they are often ineligible for liver transplantation due to their frailty and comorbidities, and effective medical treatments are still lacking. In this review we focused on pathways that are key to the aging process in the liver and perpetuate NAFLD/NASH, leading to fibrosis. In addition, we highlighted recent findings and cross-talks of normal and/or senescent liver cells, dysregulated nutrient sensing, proteostasis and mitochondrial dysfunction in the framework of changing metabolic milieu. Better understanding these pathways during preclinical and clinical studies will be essential to design novel and specific therapeutic strategies to treat NASH in the elderly.
- Subjects
NON-alcoholic fatty liver disease; FIBROSIS; AGE factors in disease
- Publication
Aging & Disease, 2022, Vol 13, Issue 4, p1239
- ISSN
2152-5250
- Publication type
Article
- DOI
10.14336/AD.2022.0318