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- Title
Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.
- Authors
Fishovitz, Jennifer; Hermoso, Juan A.; Chang, Mayland; Mobashery, Shahriar
- Abstract
High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA. © 2014 IUBMB Life, 66(8):572-577, 2014
- Subjects
METHICILLIN-resistant staphylococcus aureus; PENICILLIN-binding proteins; BETA lactam antibiotics; ALLOSTERIC regulation; BACTERIAL cell walls
- Publication
IUBMB Life, 2014, Vol 66, Issue 8, p572
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.1289