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The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461.
Published in:
Australian Journal of Chemistry, 2021, v. 74, n. 7, p. 540, doi. 10.1071/CH21049
By:
- Amarasiri, Madushani;
- Yen Vo;
- Gardiner, Michael G.;
- Poh, Perlita;
- Soo, Priscilla;
- Pavy, Megan;
- Hein, Nadine;
- Ferreira, Rita;
- Hannan, Katherine M.;
- Hannan, Ross D.;
- Banwell, Martin G.
Publication type:
Article
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.
Published in:
EMBO Journal, 2004, v. 23, n. 16, p. 3325, doi. 10.1038/sj.emboj.7600335
By:
- Poortinga, Gretchen;
- Hannan, Katherine M.;
- Snelling, Hayley;
- Walkley, Carl R.;
- Jenkins, Anna;
- Sharkey, Kerith;
- Wall, Meaghan;
- Brandenburger, Yves;
- Palatsides, Manuela;
- Pearson, Richard B.;
- McArthur, Grant A.;
- Hannan, Ross D.
Publication type:
Article
The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.
Published in:
International Journal of Molecular Sciences, 2017, v. 18, n. 1, p. 210, doi. 10.3390/ijms18010210
By:
- Shunfei Yan;
- Frank, Daniel;
- Jinbae Son;
- Hannan, Katherine M.;
- Hannan, Ross D.;
- Chan, Keefe T.;
- Pearson, Richard B.;
- Sanij, Elaine
Publication type:
Article
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
Published in:
EMBO Journal, 2020, v. 39, n. 21, p. 1, doi. 10.15252/embj.2020105111
By:
- Kusnadi, Eric P;
- Trigos, Anna S;
- Cullinane, Carleen;
- Goode, David L;
- Larsson, Ola;
- Devlin, Jennifer R;
- Chan, Keefe T;
- De Souza, David P;
- McConville, Malcolm J;
- McArthur, Grant A;
- Thomas, George;
- Sanij, Elaine;
- Poortinga, Gretchen;
- Hannan, Ross D;
- Hannan, Katherine M;
- Kang, Jian;
- Pearson, Richard B
Publication type:
Article
The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma.
Published in:
Investigational New Drugs, 2022, v. 40, n. 3, p. 529, doi. 10.1007/s10637-022-01222-w
By:
- Kang, Chang-Won;
- Hannan, Katherine M.;
- Blackburn, Anneke C.;
- Loh, Amos H. P.;
- Hong, Kuick Chik;
- Yuan, Goh Jian;
- Hein, Nadine;
- Drygin, Denis;
- Hannan, Ross D.;
- Coupland, Lucy A.
Publication type:
Article
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-12971-3
By:
- Liu, Pei Y.;
- Tee, Andrew E.;
- Milazzo, Giorgio;
- Hannan, Katherine M.;
- Maag, Jesper;
- Mondal, Sujanna;
- Atmadibrata, Bernard;
- Bartonicek, Nenad;
- Peng, Hui;
- Ho, Nicholas;
- Mayoh, Chelsea;
- Ciaccio, Roberto;
- Sun, Yuting;
- Henderson, Michelle J.;
- Gao, Jixuan;
- Everaert, Celine;
- Hulme, Amy J.;
- Wong, Matthew;
- Lan, Qing;
- Cheung, Belamy B.
Publication type:
Article
PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth.
Published in:
BMC Molecular & Cell Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s12860-020-00256-3
By:
- Thejer, Bashar M.;
- Adhikary, Partho P.;
- Kaur, Amandeep;
- Teakel, Sarah L.;
- Van Oosterum, Ashleigh;
- Seth, Ishith;
- Pajic, Marina;
- Hannan, Katherine M.;
- Pavy, Megan;
- Poh, Perlita;
- Jazayeri, Jalal A.;
- Zaw, Thiri;
- Pascovici, Dana;
- Ludescher, Marina;
- Pawlak, Michael;
- Cassano, Juan C.;
- Turnbull, Lynne;
- Jazayeri, Mitra;
- James, Alexander C.;
- Coorey, Craig P.
Publication type:
Article
Cell death and barrier disruption by clinically used iodine concentrations.
Published in:
Life Science Alliance, 2023, v. 6, n. 6, p. 1, doi. 10.26508/lsa.202201875
By:
- Steins, Anne;
- Carroll, Christina;
- Fui Jiun Choong;
- George, Amee J.;
- Jin-Shu He;
- Parsons, Kate M.;
- Shouya Feng;
- Si Ming Man;
- Kam, Cathelijne;
- van Loon, Lex M.;
- Poh, Perlita;
- Ferreira, Rita;
- Mann, Graham J.;
- Gruen, Russell L.;
- Hannan, Katherine M.;
- Hannan, Ross D.;
- Schulte, Klaus-Martin
Publication type:
Article
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest.
Published in:
Oncogene, 2000, v. 19, n. 31, p. 3487, doi. 10.1038/sj.onc.1203690
By:
- Hannan, Katherine M;
- Kennedy, Brian K;
- Cavanaugh, Alice H;
- Hannan, Ross D;
- Hirschler-Laszkiewicz, Iwona;
- Jefferson, Leonard S;
- Rothblum, Lawrence I
Publication type:
Article
AKT signalling is required for ribosomal RNA synthesis and progression of Eμ- Myc B-cell lymphoma in vivo.
Published in:
FEBS Journal, 2013, v. 280, n. 21, p. 5307, doi. 10.1111/febs.12135
By:
- Devlin, Jennifer R.;
- Hannan, Katherine M.;
- Ng, Pui Y.;
- Bywater, Megan J.;
- Shortt, Jake;
- Cullinane, Carleen;
- McArthur, Grant A.;
- Johnstone, Ricky W.;
- Hannan, Ross D.;
- Pearson, Richard B.
Publication type:
Article
High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology.
Published in:
Assay & Drug Development Technologies, 2018, v. 16, n. 6, p. 320, doi. 10.1089/adt.2018.861
By:
- He, Jin-Shu;
- Soo, Priscilla;
- Evers, Maurits;
- Parsons, Kate M.;
- Hein, Nadine;
- Hannan, Katherine M.;
- Hannan, Ross D.;
- George, Amee J.
Publication type:
Article
Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.
Published in:
Assay & Drug Development Technologies, 2016, v. 14, n. 7, p. 416, doi. 10.1089/adt.2016.739
By:
- Chan, Keefe T.;
- Hannan, Ross D.;
- Pearson, Richard B.;
- Paavolainen, Lassi;
- Horvath, Peter;
- Hannan, Katherine M.;
- George, Amee J.;
- Simpson, Kaylene J.
Publication type:
Article
UBF levels determine the number of active ribosomal RNA genes in mammals.
Published in:
Journal of Cell Biology, 2008, v. 183, n. 7, p. 1259, doi. 10.1083/jcb.200805146
By:
- Sanij, Elaine;
- Poortinga, Gretchen;
- Sharkey, Kerith;
- Hung, Sandy;
- Holloway, Timothy P.;
- Quin, Jaclyn;
- Robb, Elysia;
- Wong, Lee H.;
- Thomas, Walter G.;
- Stefanovsky, Victor;
- Moss, Tom;
- Rothblum, Lawrence;
- Hannan, Katherine M.;
- McArthur, Grant A.;
- Pearson, Richard B.;
- Hannan, Ross D.
Publication type:
Article
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Published in:
2021
By:
- Yan, Shunfei;
- Xuan, Jiachen;
- Brajanovski, Natalie;
- Tancock, Madeleine R. C.;
- Madhamshettiwar, Piyush B.;
- Simpson, Kaylene J.;
- Ellis, Sarah;
- Kang, Jian;
- Cullinane, Carleen;
- Sheppard, Karen E.;
- Hannan, Katherine M.;
- Hannan, Ross D.;
- Sanij, Elaine;
- Pearson, Richard B.;
- Chan, Keefe T.
Publication type:
journal article
Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies.
Published in:
Biomedicines, 2023, v. 11, n. 4, p. 1133, doi. 10.3390/biomedicines11041133
By:
- Kang, Chang-Won;
- Blackburn, Anneke C.;
- Loh, Amos Hong Pheng;
- Hong, Kuick Chick;
- Goh, Jian Yuan;
- Hein, Nadine;
- Drygin, Denis;
- Parish, Chris R.;
- Hannan, Ross D.;
- Hannan, Katherine M.;
- Coupland, Lucy A.
Publication type:
Article
Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age.
Published in:
Cells (2073-4409), 2020, v. 9, n. 2, p. 266, doi. 10.3390/cells9020266
By:
- Ferreira, Rita;
- Schneekloth, John S.;
- Panov, Konstantin I.;
- Hannan, Katherine M.;
- Hannan, Ross D.
Publication type:
Article
Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.
Published in:
Enzyme Research, 2011, p. 1, doi. 10.4061/2011/720985
By:
- Lee, Rachel S.;
- House, Colin M.;
- Cristiano, Briony E.;
- Hannan, Ross D.;
- Pearson, Richard B.;
- Hannan, Katherine M.
Publication type:
Article
Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis.
Published in:
PLoS Genetics, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.pgen.1003279
By:
- Boglev, Yeliz;
- Badrock, Andrew P.;
- Trotter, Andrew J.;
- Qian Du;
- Richardson, Elsbeth J.;
- Parslow, Adam C.;
- Markmiller, Sebastian J.;
- Hall, Nathan E.;
- de Jong-Curtain, Tanya A.;
- Ng, Annie Y.;
- Verkade, Heather;
- Ober, Elke A.;
- Field, Holly A.;
- Donghun Shin;
- Shin, Chong H.;
- Hannan, Katherine M.;
- Hannan, Ross D.;
- Pearson, Richard B.;
- Seok-Hyung Kim;
- Ess, Kevin C.
Publication type:
Article
New Roles for the Nucleolus in Health and Disease.
Published in:
BioEssays, 2018, v. 40, n. 5, p. 1, doi. 10.1002/bies.201700233
By:
- Núñez Villacís, Lorena;
- Wong, Mei S.;
- Ferguson, Laura L.;
- Hein, Nadine;
- George, Amee J.;
- Hannan, Katherine M.
Publication type:
Article
Signaling to the ribosome in cancer-It is more than just mTORC1.
Published in:
IUBMB Life, 2011, v. 63, n. 2, p. 79, doi. 10.1002/iub.428
By:
- Hannan, Katherine M.;
- Sanij, Elaine;
- Hein, Nadine;
- Hannan, Ross D.;
- Pearson, Richard B.
Publication type:
Article
Signaling to the ribosome in cancer-It is more than just mTORC1.
Published in:
2011
By:
- Hannan, Katherine M.;
- Sanij, Elaine;
- Hein, Nadine;
- Hannan, Ross D.;
- Pearson, Richard B.
Publication type:
Other
Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70<sup>s6k</sup>/p85<sup>s6k</sup>: implications for the analysis of S6K signalling
Published in:
FEBS Letters, 2002, v. 519, n. 1-3, p. 135, doi. 10.1016/S0014-5793(02)02738-2
By:
- Marmy-Conus, Nelly;
- Hannan, Katherine M.;
- Pearson, Richard B.
Publication type:
Article
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16393-4
By:
- Sanij, Elaine;
- Hannan, Katherine M.;
- Xuan, Jiachen;
- Yan, Shunfei;
- Ahern, Jessica E.;
- Trigos, Anna S.;
- Brajanovski, Natalie;
- Son, Jinbae;
- Chan, Keefe T.;
- Kondrashova, Olga;
- Lieschke, Elizabeth;
- Wakefield, Matthew J.;
- Frank, Daniel;
- Ellis, Sarah;
- Cullinane, Carleen;
- Kang, Jian;
- Poortinga, Gretchen;
- Nag, Purba;
- Deans, Andrew J.;
- Khanna, Kum Kum
Publication type:
Article
AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer.
Published in:
Science Signaling, 2011, v. 4, n. 188, p. 1, doi. 10.1126/scisignal.2001754
By:
- Chan, Joanna C.;
- Hannan, Katherine M.;
- Riddell, Kim;
- Ng, Pui Yee;
- Peck, Abigail;
- Lee, Rachel S.;
- Hung, Sandy;
- Astle, Megan V.;
- Bywater, Megan;
- Wall, Meaghan;
- Poortinga, Gretchen;
- Jastrzebski, Katarzyna;
- Sheppard, Karen E.;
- Hemmings, Brian A.;
- Hall, Michael N.;
- Johnstone, Ricky W.;
- McArthur, Grant A.;
- Hannan, Ross D.;
- Pearson, Richard B.
Publication type:
Article

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