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- Title
Prospective evaluation of planar bone scintigraphy, SPECT, SPECT/CT, F-NaF PET/CT and whole body 1.5T MRI, including DWI, for the detection of bone metastases in high risk breast and prostate cancer patients: SKELETA clinical trial.
- Authors
Jambor, Ivan; Aronen, Hannu J.; Kuisma, Anna; Ramadan, Susan; Huovinen, Riikka; Minn, Heikki; Sandell, Minna; Auren, Joakim; Saunavaara, Jani; Kajander, Sami; Kemppainen, Jukka; Merisaari, Harri; Seppänen, Marko; Kauppila, Esa; Noponen, Tommi
- Abstract
Purpose.Detection of bone metastases in breast and prostate cancer patients remains a major clinical challenge. The aim of the current trial was to compare the diagnostic accuracy of99mTc-hydroxymethane diphosphonate (99mTc-HDP) planar bone scintigraphy (BS),99mTc-HDP SPECT,99mTc-HDP SPECT/CT,18F-NaF PET/CT and whole body 1.5 Tesla magnetic resonance imaging (MRI), including diffusion weighted imaging, (wbMRI+DWI) for the detection of bone metastases in high risk breast and prostate cancer patients. Material and methods.Twenty-six breast and 27 prostate cancer patients at high risk of bone metastases underwent99mTc-HDP BS,99mTc-HDP SPECT,99mTc-HDP SPECT/CT,18F-NaF PET/CT and wbMRI+DWI. Five independent reviewers interpreted each individual modality without the knowledge of other imaging findings. The final metastatic status was based on the consensus reading, clinical and imaging follow-up (minimal and maximal follow-up time was 6, and 32 months, respectively). The bone findings were compared on patient-, region-, and lesion-level. Results.99mTc-HDP BS was false negative in four patients. In the region-based analysis, sensitivity values for99mTc-HDP BS,99mTc-HDP SPECT,99mTc-HDP SPECT/CT,18F-NaF PET/CT, and wbMRI+DWI were 62%, 74%, 85%, 93%, and 91%, respectively. The number of equivocal findings for99mTc-HDP BS,99mTc-HDP SPECT,99mTc-HDP SPECT/CT,18F-NaF PET/CT and wbMRI+DWI was 50, 44, 5, 6, and 4, respectively. Conclusion.wbMRI+DWI showed similar diagnostic accuracy to18F-NaF PET/CT and outperformed99mTc-HDP SPECT/CT, and99mTc-HDP BS.
- Subjects
BONE metastasis; BREAST tumor risk factors; PROSTATE tumors; COMPUTED tomography; DIAGNOSTIC imaging; DIPHOSPHONATES; LONGITUDINAL method; MAGNETIC resonance imaging; RADIONUCLIDE imaging; RESEARCH funding; SINGLE-photon emission computed tomography; DATA analysis software; DIAGNOSIS; TUMOR risk factors
- Publication
Acta Oncologica, 2016, Vol 55, Issue 1, p59
- ISSN
0284-186X
- Publication type
Article
- DOI
10.3109/0284186X.2015.1027411