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- Title
Daily low-dose/continuous capecitabine combined with neo-adjuvant irradiation reduces VEGF and PDGF-BB levels in rectal carcinoma patients.
- Authors
Loven, David; Be'Ery, Einat; Yerushalmi, Rinat; Koren, Claude; Sulkes, Aaron; Lavi, Idit; Shaked, Yuval; Fenig, Eyal
- Abstract
Metronomic low-dose chemotherapy regimen was found to have an antiangiogenic effect in tumors. However, its effect on levels of circulating pro-angiogenic and anti-angiogenic factors is not fully explored. Materials and methods. The levels of both VEGF and PDGF-BB were measured in three time points, in the serum of 32 rectal carcinoma patients receiving daily reduced-dose/continuous capecitabine in combination with preoperative pelvic irradiation. Results. We found a significant decrease in VEGF and PDGF-BB serum levels during the combination treatment (p<0.0001), followed by an increase in the successive rest-period (p<0.0001). In addition, substantial changes in platelets counts were observed during treatment in correlation with the changes of VEGF and PDGF-BB serum levels. Discussion. These results suggest that combined chemo-irradiation affect levels of pro-angiogenic factors during treatment, and may reflect an anti-angiogenic window induced during this treatment. The potential implications of this inducible phenomenon, including a possible clinical benefit from the administration of long lasting metronomic chemotherapy immediately following combined chemo-irradiation, would warrant further investigation.
- Subjects
ADJUVANT treatment of cancer; IRRADIATION; VASCULAR endothelial growth factors; RECTAL cancer patients; DRUG therapy
- Publication
Acta Oncologica, 2008, Vol 47, Issue 1, p104
- ISSN
0284-186X
- Publication type
Article
- DOI
10.1080/02841860701472470