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- Title
Roles of Extracellular Vesicles in Metastatic Breast Cancer.
- Authors
Peng, Junya; Wang, Wenqian; Hua, Surong; Liu, Lulu
- Abstract
Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. This review also covers EV roles as biomarker and therapeutic target in clinical application.
- Subjects
BIOMARKERS; BREAST tumors; CELL physiology; EXTRACELLULAR space; MEMBRANE proteins; METASTASIS
- Publication
Breast Cancer: Basic & Clinical Research, 2018, Issue 12, p1
- ISSN
1178-2234
- Publication type
Article
- DOI
10.1177/1178223418767666