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- Title
The Efficacy of Intraoperative Frozen Section Analysis During Breast-Conserving Surgery for Patients with Ductal Carcinoma In Situ.
- Authors
Mi Jin Kim; Cheol Seung Kim; Young Sam Park; Eun Hye Choi; Kyu Dam Han
- Abstract
INTRODUCTION: Recently, the incidence of ductal carcinoma in situ (DCIS), a noninvasive breast malignancy, has increased. This has resulted in an increase in the incidence of breast-conserving surgery (BCS). Numerous studies have suggested that intraoperative frozen section analysis (IFSA) could reduce the rate of additional excisions required to obtain adequate resection margins. However, DCIS is a known risk factor for positive margin status during BCS. Furthermore, some authors have concluded that IFSA may not be reliable for the detection of DCIS. AIM: The aim of this study was to evaluate the safety and efficacy of IFSA in patients with DCIS. METHODS: The operative and pathological reports of patients with DCIS, who underwent BCS at our institute between 2006 and 2015, were retrospectively reviewed. The results of IFSA and the pathological findings of final reanalyzed frozen tissue specimens were analyzed. RESULTS: In total, 25 patients were included in our analysis. None of the patients required additional operations. The correct diagnosis rate for IFSA was 89.6%, with a sensitivity and specificity of 60.0% and 95.8%, respectively. CONCLUSION: IFSA could be beneficial for determining safety resection margins in patients with DCIS.
- Publication
Breast Cancer: Basic & Clinical Research, 2016, Issue 10, p205
- ISSN
1178-2234
- Publication type
Article
- DOI
10.4137/BCBCr.s40868