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- Title
Effectiveness of Pandemic H1N1-2009 Vaccination in Reducing Laboratory Confirmed Influenza Infections among Military Recruits in Tropical Singapore.
- Authors
Lee, Vernon J.; Chi Hsien Tan; Jonathan Yap; Cook, Alex R.; Pei-Jun Ting; Jin-Phang Loh; Qiuhan Gao; Chen, Mark I.; Wee Lee Kang; Boon Huan Tan; Tambyah, Paul A.
- Abstract
Background: Limited information is available about pandemic H1N1-2009 influenza vaccine effectiveness in tropical communities. We studied the effectiveness of a pandemic H1N1 vaccination program in reducing influenza cases in Singapore. Methods: A surveillance study was conducted among military personnel presenting with febrile respiratory illness from mid- 2009 to mid-2010. Consenting individuals underwent nasal washes, which were tested with RT-PCR and subtyped. A vaccination program (inactivated monovalent Panvax H1N1-2009 vaccine) was carried out among recruits. A Bayesian hierarchical model was used to quantify relative risks in the pre- and post-vaccination periods. An autoregressive generalised linear model (GLM) was developed to minimise confounding. Results: Of 2858 participants, 437(15.3%), 60(2.1%), and 273(9.6%) had pandemic H1N1, H3N2, and influenza B. The ratio of relative risks for pandemic H1N1 infection before and after vaccination for the recruit camp relative to other camps was 0.14(0.016,0.49); for H3N2, 0.44(0.035,1.8); and for influenza B, 18(0.77,89). Using the GLM for the recruit camp, postvaccination weekly cases decreased by 54%(37%,67%, p<0.001) from that expected without vaccination; influenza B increased by 66 times(9-479 times, p<0.001); with no statistical difference for H3N2 (p = 0.54). Conclusions: Pandemic vaccination reduced H1N1-2009 disease burden among military recruits. Routine seasonal influenza vaccination should be considered.
- Subjects
SINGAPORE; H1N1 influenza; INFLUENZA vaccines; PANDEMICS; VACCINATION; LINEAR statistical models
- Publication
PLoS ONE, 2011, Vol 6, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0026572