We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Computational models of neuron-astrocyte interaction in epilepsy.
- Authors
Volman, Vladislav; Bazhenov, Maxim; Sejnowski, Terrence J.
- Abstract
Astrocytes actively shape the dynamics of neurons and neuronal ensembles by affecting several aspects critical to neuronal function, such as regulating synaptic plasticity, modulating neuronal excitability, and maintaining extracellular ion balance. These pathways for astrocyte-neuron interaction can also enhance the information-processing capabilities of brains, but in other circumstances may lead the brain on the road to pathological ruin. In this article, we review the existing computational models of astrocytic involvement in epileptogenesis, focusing on their relevance to existing physiological data.
- Subjects
EPILEPSY; NEURONS; ASTROCYTES; NEUROPLASTICITY; EXTRACELLULAR matrix; IONS
- Publication
Frontiers in Computational Neuroscience, 2012, Vol 6, p1
- ISSN
1662-5188
- Publication type
Article
- DOI
10.3389/fncom.2012.00058