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- Title
Atrial Natriüretik Peptidin Kronik İmmobilizasyon Stresine Maruz Bırakılmış Sıçanlarda Davranışsal Umutsuzluk Üzerine Etkisi.
- Authors
Yıldırım, Ejder Akgün; Mengi, Murat; Turhan, Sibel; Yurdakoş, Ertan
- Abstract
Objectives: Anxiolytic efficacy of atrial natriuretic peptide (ANP) was shown in experimental studies. In our study, we evaluated the effect of intracerebroventricular administration of ANP on behavioral despair in rats exposed to chronic immobilization stress. Method: In this study, Wistar-Albino male adult rats weighing 250-300 g have been used. Study animals were randomly assigned into four groups. 1-Control group: Group did not undergone surgical intervention and did not received substance injection (n=8). 2-Sham operated group: Group was administered 5 µl physiologic serum via intracerebroventricular route (n=8). 3-Chronic immobilization group: Group was exposed to 7 minutes daily immobilization stress for two weeks and was administered 5 µl physiologic serum via intracerebroventricular route (n=8). 4-ANP group: Group was exposed to 7 minutes daily immobilization stress for two weeks and administered 0.5 µg/5 µl intracerebroventricular ANP (n=8). As behavioral test, Porsolt's swimming test was used. The results were analyzed statistically by using one-way ANOVA-Turkey and Wilcoxon tests. Results: In the Porsolt's Swimming test, the control and the sham operated group animals exhibited the well-documented behavioral despair by a significant increase in immobilization time when compared with that of the pre-test. On the other hand, compared with the control and the sham-operated group, animals in the chronic immobilization group and ANP administered group did not show behavioral despair obviously. Conclusion: These results suggest that in Porsolt's swimming test, both chronic mild stress and intracerebroventricular ANP administration in the rats exposed to chronic mild (immobilization) stress have preventive effects on the development of behavioral despair, but the direct role of ANP in these effects is not clear.
- Subjects
ATRIAL natriuretic peptides; BEHAVIORAL assessment; LABORATORY rats; CHRONIC diseases; IMMOBILIZATION stress; DRUG administration
- Publication
Klinik Psikiyatri Dergisi, 2012, Vol 15, Issue 1, p7
- ISSN
1302-0099
- Publication type
Article