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- Title
Association between Fiber Intake and Risk of Incident Chronic Kidney Disease: The UK Biobank Study.
- Authors
Heo, G. Y.; Kim, H. J.; Kalantar, D.; Jung, C. Y.; Kim, H. W.; Park, J. T.; Chang, T. I.; Yoo, T. H.; Kang, S. W.; Rhee, C. M.; Kalantar-Zadeh, K.; Han, Seung Hyeok
- Abstract
Objectives: Dietary fiber intake is associated with a lower risk of diabetes, cardiovascular disease, and cancer. However, it is unknown whether dietary fiber has a beneficial effect on preventing the development of chronic kidney disease (CKD). Design, Setting, Participants and Measurements: Using the UK Biobank prospective cohort, 110,412 participants who completed at least one dietary questionnaire and had an estimated glomerular filtration rate ≥60 mL/min/1.73 m2, urinary albumin-to-creatinine ratio <30 mg/g, and no history of CKD were included. The primary exposure was total dietary fiber density, calculated by dividing the absolute amount of daily total fiber intake by total energy intake (g/1,000 kcal). We separately examined soluble and insoluble fiber densities as additional predictors. The primary outcome was incident CKD based on diagnosis codes. Results: A total of 3,507 (3.2%) participants developed incident CKD during a median follow-up of 9.9 years. In a multivariable cause-specific model, the adjusted hazard ratios (aHRs; 95% confidence intervals [CIs]) for incident CKD were 0.85 (0.77–0.94), 0.78 (0.70–0.86), and 0.76 (0.68–0.86), respectively, for the second, third, and highest quartiles of dietary fiber density (reference: lowest quartile). In a continuous model, the aHR for each +Δ1.0g/1,000 kcal increase in dietary fiber density was 0.97 (95% CI, 0.95–0.99). This pattern of associations was similar for both soluble and insoluble fiber densities and did not differ across subgroups of sex, age, body mass index, hypertension, diabetes, smoking, and inflammation. Conclusion: Increased fiber intake was associated with a lower risk of CKD in this large well-characterized cohort.
- Subjects
UNITED Kingdom; CHRONIC kidney failure; DIETARY fiber; GLOMERULAR filtration rate; ALBUMINS; NUTRIENT density; CONFIDENCE intervals; FOOD consumption; RISK assessment; QUESTIONNAIRES; DESCRIPTIVE statistics; LONGITUDINAL method; CREATININE; DISEASE risk factors
- Publication
Journal of Nutrition, Health & Aging, 2023, Vol 27, Issue 11, p1018
- ISSN
1279-7707
- Publication type
Article
- DOI
10.1007/s12603-023-1998-6