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- Title
Tailored management of primary gastrointestinal stromal tumors.
- Authors
Etherington, Mark S.; DeMatteo, Ronald P.
- Abstract
Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and can form along the entire gastrointestinal tract. Over the last 20 years, considerable advances have been made in our understanding of the biology of GISTs. The advent of tyrosine kinase inhibitors has provided effective medical therapy for the first time. In fact, given that GIST typically is driven by either a KIT or PDGFRA gene mutation, it has become a paradigm of targeted molecular therapy. In addition, diagnostic and surgical techniques have been refined. Here, the critical aspects of primary GISTs and how they are now managed with an integrated approach are summarized. Treatment plans are developed based on specific pathologic and molecular features of the tumor. The authors outline the general principles of therapy and highlight some of the nuances. Particular focus is given to diagnosis, surgical considerations, and the use of preoperative and postoperative tyrosine kinase inhibitors. The multidisciplinary management of primary gastrointestinal stromal tumors has evolved considerably over the last 20 years. Herein, the surgical and medical considerations are reviewed.
- Subjects
GASTROINTESTINAL stromal tumors; PROTEIN-tyrosine kinases; KINASE inhibitors; THERAPEUTICS
- Publication
Cancer (0008543X), 2019, Vol 125, Issue 13, p2164
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.32067