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- Title
Lifestyle and the Risk of Dementia in Japanese-American Men.
- Authors
Gelber, Rebecca P.; Petrovitch, Helen; Masaki, Kamal H.; Abbott, Robert D.; Ross, George Webster; Launer, Lenore J.; White, Lon R.
- Abstract
Objectives To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia. Design Case-control study nested in a prospective cohort. Setting The Honolulu-Asia Aging Study, Oahu, Hawaii. Participants Three thousand four hundred sixty-eight Japanese- American men (mean age 52 in 1965-1968) examined for dementia 25 years later. Measurements Men at low risk were defined as those with the following midlife characteristics: nonsmoking, body mass index (BMI) less than 25.0 kg/m2, physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated to saturated fat). Logistic regression was used to calculate odds ratios ( ORs) and 95% confidence intervals ( CIs) for developing overall dementia, Alzheimer's disease ( AD), and vascular dementia ( VaD), adjusting for potential confounders. Results Dementia was diagnosed in 6.4% of men (52.5% with AD, 35.0% with VaD). Examining the risk factors individually, BMI was most strongly associated with greater risk of overall dementia ( OR = 1.87, 95% CI = 1.26-2.77; BMI > 25.0 vs <22.6 kg/m2). All of the individual risk factors except diet score were significantly associated with VaD, whereas none were significantly associated with AD alone. Men with all four low-risk characteristics (7.2% of the cohort) had the lowest OR for overall dementia ( OR = 0.36, 95% CI = 0.15-0.84). There were no significant associations between the combined low-risk characteristics and the risk of AD alone. Conclusion Among Japanese-American men, having a healthy lifestyle in midlife is associated with a lower risk of dementia in late life.
- Subjects
HAWAII; DIAGNOSIS of dementia; DEMENTIA risk factors; ANALYSIS of covariance; CONFIDENCE intervals; DEMENTIA; DIET; EPIDEMIOLOGY; HEALTH behavior; JAPANESE people; LONGITUDINAL method; RESEARCH funding; RISK assessment; LOGISTIC regression analysis; DATA analysis; LIFESTYLES; CASE-control method; DATA analysis software; OLD age
- Publication
Journal of the American Geriatrics Society, 2012, Vol 60, Issue 1, p118
- ISSN
0002-8614
- Publication type
Article
- DOI
10.1111/j.1532-5415.2011.03768.x