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- Title
Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection.
- Authors
Anzala OA; Nagelkerke NJ; Bwayo JJ; Holton D; Moses S; Ngugi EN; Ndinya-Achola JO; Plummer FA; Anzala, O A; Nagelkerke, N J; Bwayo, J J; Holton, D; Moses, S; Ngugi, E N; Ndinya-Achola, J O; Plummer, F A
- Abstract
From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.
- Publication
Journal of Infectious Diseases, 1995, Vol 171, Issue 3, p686
- ISSN
0022-1899
- Publication type
journal article