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- Title
Safety, Immunogenicity, and Transmissibility of Single-Dose Live Oral Cholera Vaccine Strain CVD l03-HgR in 24- to 59-Month-Old Indonesian Children.
- Authors
Simanjuntak, Cyrus H.; O'Hanley, Peter; Punjabi, Narain H.; Noriega, Fernando; Pazzaglia, Gary; Dykstra, Patricia; Kay, Bradford; Suharyono; Budiarso, Aswitha; Rifai, Atti R.; Wasserman, Steven S.; Losonsky, Genevieve; Kaper, James; Cryz, Stanley; Levine, Myron M.
- Abstract
Recombinant A-B+ Vibrio cholerae O1 strain CVD 103-HgR is a safe, highly immunogenic, single-dose live oral vaccine in adults in industrialized countries, Safety, excretion, immunogenicity, vaccine transmissibility, and environmental introduction ofCVD 103-HgR were investigated among 24- to 59-month-old children in Jakarta. In 81 households, 1 child was randomly allocated a single dose of vaccine (5 x 109 cfu) and another, placebo. Additionally, 139 unpaired children were randomly allocated vaccine or placebo. During 9 days of follow-up, diarrhea or vomiting did not occur more often among vaccinees than controls. Vaccine was minimally excreted and was isolated from no controls and from 1 (0.6%) of 177 unvaccinated family contacts. A 4-fold or higher rise in serum vibriocidal antibody was observed in 75% of vaccinees (10-fold rise in geometric mean titer over baseline). Of 135 paired placebo recipients or household contacts, 5 had vibriocidal seroconversions. Moore swabs placed in sewers and latrines near 97 households failed to detect vaccine. These observations pave the way for a large-scale field trial of efficacy.
- Publication
Journal of Infectious Diseases, 1993, Vol 168, Issue 5, p1169
- ISSN
0022-1899
- Publication type
Article