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- Title
Ethyl Acetate Extract of the Stem Bark of Cudrania Tricuspidata Induces Apoptosis in Human Leukemia HL-60 Cells.
- Authors
Seo, Won-Gil; Pae, Hyun-Ock; Oh, Gi-Su; Chai, Kyu-Yun; Yun, Young-Gab; Chung, Hun-Taeg; Jang, Kyu Kwan; Kwon, Tae-Oh
- Abstract
Apoptosis is now widely accepted as playing a role in tumorigenesis. An effective compound which can kill tumors via apoptonic pathway appears to be a relevant strategy to suppress various human tumors. The ethyl acetate extract from the stem bark of Cudrania tricupidata (EACT) showed dose- and time-dependent cytotoxic effects on human leukemia HL-60 cells. DNA fragmentation and morphological changes, accompanied by condensed and fragmented nuclei, were observed in the cells cultured for 6 hr with EACT. These results suggest that the cytotoxicity of the crude extract from Cudrania tricuspidata against HL-60 cells is due to apoptosis.
- Publication
American Journal of Chinese Medicine, 2001, Vol 29, Issue 2, p313
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/s0192415x01000332