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- Title
Anti-Allergic Inflammatory Effects of Hepatocyte Growth Factor.
- Authors
Ito, Wataru; Takeda, Masahide; Tanabe, Masako; Kihara, Junko; Kato, Hikari; Chiba, Takahito; Yamaguchi, Kazutoshi; Ueki, Shigeharu; Kanehiro, Arihiko; Kayaba, Hiroyuki; Chihara, Junichi
- Abstract
Hepatocyte growth factor (HGF) is known to influence a number of cell types and regulate various biological activities including cytokine production, cell migration, proliferation and survival. Thus, HGF is now recognized to be a key factor in the prevention and attenuation of disease progression. We have reported that HGF reduces allergic airway inflammation, airway hyperresponsiveness, remodeling and development of Th2 cytokines as well as growth factors such as transforming growth factor-β in vivo. In vitro, HGF directly attenuates chemotaxis of eosinophils in the absence of Th2 cytokines and modulates mitogen-activated protein kinases, which play an important role in eosinophil migration. In this review, we discuss the physiological role of HGF in allergic inflammation and its mechanism of anti-inflammatory effects, including the regulation of eosinophil functions. Copyright © 2008 S. Karger AG, Basel
- Subjects
ANTIALLERGIC agents; HEPATOCYTE growth factor; CYTOKINES; CELL migration; CELL proliferation; EOSINOPHILS
- Publication
International Archives of Allergy & Immunology, 2008, Vol 146, p82
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000126067