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- Title
Testicular yolk sac tumors in children: a review of 61 patients over 19 years.
- Authors
Yi Wei; Shengde Wu; Tao Lin; Dawei He; Xuliang Li; Junhong Liu; Xing Liu; Yi Hua; Peng Lu; Guanghui Wei
- Abstract
Objective To describe 19 years of clinical experience managing pediatric patients with testicular yolk sac tumors at the Chongqing Medical University Affiliated Children's Hospital. Methods This study involved a retrospective review of the records of 61 pediatric patients who presented with testicular yolk sac tumor at our institution between 1995 and 2014. Results All patients presented with a painless scrotal mass. Serum alpha-fetoprotein (AFP) levels were elevated (n = 15). Ultrasonography identified the yolk sac tumors as solid masses. Color Doppler flow imaging showed rich blood flow inside and around the masses in 84.8% cases. X-ray of the scrotum showed no intrascrotal calcification (n = 38). Inguinal orchiectomy was performed in 60 patients, one case was treated with testis-sparing surgery. In 11 cases, radical dissection of the inguinal lymph nodes was performed. Histological analysis showed pathologies typical of yolk sac tumor including microcapsule and reticular structures, gland tube-gland bubble structures, an embryo sinus structure, and papillary structures. All patients received postoperative chemotherapy. Serum AFP levels returned to normal 1 to 2 months after surgery. No patients treated with surgery in our hospital relapsed. Conclusion Testicular yolk sac tumor presents as a painless scrotal mass, increased serum AFP levels, and a solid mass on ultrasound. Chest radiography and abdominal ultrasound should be used to accurately stage the tumor. We advocate for inguinal orchiectomy for Stage I disease and postoperative chemotherapy to prevent recurrence in the ipsilateral or contralateral testis.
- Subjects
TESTICULAR diseases; JUVENILE diseases; COLOR Doppler ultrasonography; DIAGNOSTIC imaging; CANCER chemotherapy
- Publication
World Journal of Surgical Oncology, 2014, Vol 12, Issue 1, p1
- ISSN
1477-7819
- Publication type
Article
- DOI
10.1186/1477-7819-12-400