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- Title
Can we microbe-manage our vitamin acquisition for better health?
- Authors
Nysten, Jana; Van Dijck, Patrick
- Abstract
Besides vitamin secretion, commensals in the GI tract can convert dietary vitamin A into active vitamin A metabolites, which are important for maintaining epithelial homeostasis and immune function. The advantages of vitamin production by gut microbiota The human GI tract harbors a large and complex population of microorganisms that offers a range of physiological functions and are consequently imperative for the host's health [[1]]. Especially the riboflavin (vitamin B SB 2 sb ), pantothenic acid (vitamin B SB 5 sb ), and folate (vitamin B SB 9 sb ) biosynthesis pathways seem to be interesting drug targets as they are well conserved among fungi and essential for fungal growth [[49]]. Most of the human GI tract's commensals can biosynthesize and secrete vitamin K and B group vitamins, but besides excess vitamin biosynthesis, the gut microbiota can also convert dietary vitamin A precursors into retinoic acid, a key regulator of gene expression [[12]].
- Subjects
GUT microbiome; VITAMINS; WATER-soluble vitamins; FAT-soluble vitamins; VITAMIN B complex; VITAMIN K
- Publication
PLoS Pathogens, 2023, Vol 18, Issue 5, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1011361