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- Title
Association of dietary vitamin E intake with risk of lung cancer: a dose-response meta-analysis.
- Authors
Yong-Jian Zhu; Ya-Cong Bo; Xin-Xin Liu; Chun-Guang Qiu; Zhu, Yong-Jian; Bo, Ya-Cong; Liu, Xin-Xin; Qiu, Chun-Guang
- Abstract
<bold>Background and Objectives: </bold>Several epidemiological studies investigating the association between dietary vitamin E intake and the risk of lung cancer have demonstrated inconsistent results. Hence, a meta-analysis was conducted to summarise evidence of the association of dietary vitamin E intake with the risk of lung cancer.<bold>Methods and Study Design: </bold>In this meta-analysis, a systematic literature search of PubMed and Web of Science was conducted to identify relevant studies published from 1955 to April 2015. If p<0.05 or I2 >50%, a random effect model was used to estimate overall relative risks (RRs) and 95% confidence intervals (CIs). Otherwise, a fixed effect model was applied. Publication bias was estimated using the funnel plot and Egger's test. The doseresponse relationship was assessed using the method of restricted cubic splines with 4 knots at percentiles 5, 35, 65, and 95 of the distribution.<bold>Results: </bold>The pooled RR of lung cancer for the highest versus lowest categories of dietary vitamin E intake was 0.84 (95% CI=0.76-0.93). With every 2 mg/d increase in dietary vitamin E intake, the risk of lung cancer statistically decreased by 5% (RR=0.95, 95% CI =0.91-0.99, plinearity=0.0237).<bold>Conclusions: </bold>Our analysis suggests that higher dietary vitamin E intake exerts a protective effect against lung cancer.
- Subjects
VITAMIN E; DIETARY supplements; LUNG cancer risk factors; DOSE-response relationship in biochemistry; EPIDEMIOLOGY of cancer; COMPARATIVE studies; DIET; DOSE-effect relationship in pharmacology; LUNG tumors; RESEARCH methodology; MEDICAL cooperation; META-analysis; RESEARCH; EVALUATION research; RELATIVE medical risk; PREVENTION
- Publication
Asia Pacific Journal of Clinical Nutrition, 2017, Vol 26, Issue 2, p271
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.032016.04