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- Title
LncRNA ZEB1-AS1 contributes to STAT3 activation by associating with IL-11 in B-lymphoblastic leukemia.
- Authors
Wang, Qing; Du, Xiaoli; Yang, Min; Xiao, Shishan; Cao, Jun; Song, Jun; Wang, Linhui
- Abstract
Objective: To investigate the role of lncRNA ZEB1-AS1 in B-lineage acute lymphoblastic leukemia (B-ALL). Results: ZEB1-AS1 levels were aberrantly up-regulated in B-ALL. All correlated with STAT3 activation and IL-11 production. Moreover, a high level of ZEB1-AS1 predicted poor prognosis of B-ALL patients. Mechanistically, ZEB1-AS1 could bind to IL-11 and promote IL-11 stability. Down-regulation of ZEB1-AS1 decreased IL-11 production of human bone marrow stromal cells (BMSCs), which led to suppressed proliferation and inhibited IL-11/STAT3 pathway in BALL-1 cells. Conclusions: ZEB1-AS1 promotes the activation of IL-11/STAT3 signaling pathway by associating with IL-11 in B-ALL.
- Subjects
LYMPHOBLASTIC leukemia diagnosis; MESENCHYMAL stem cells; INTERLEUKIN receptors; HUMAN cytogenetics; PHYSIOLOGY
- Publication
Biotechnology Letters, 2017, Vol 39, Issue 12, p1801
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-017-2421-3