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- Title
The effects of PG102, a water-soluble extract from Actinidia arguta, on serum total IgE levels: a double-blind, randomized, placebo-controlled exploratory clinical study.
- Authors
Kim, Sae-Hoon; Kim, Sunyoung; Lee, So-Hee; Park, Heung-Woo; Chang, Yoon-Seok; Min, Kyung-Up; Cho, Sang-Heon
- Abstract
Background: Recent studies have reported that blocking IgE has a potentially beneficial role in the treatment of various allergic diseases. Previously, we found that PG102, a water-soluble extract prepared from the edible fruits of Actinidia arguta, can effectively reduce IgE levels using murine models. Aims: To evaluate the efficacy of PG102 at lowering levels of total IgE in asymptomatic subjects with atopy. Methods: A total of 90 asymptomatic subjects with atopy were randomized equally to a PG102 group or a placebo control group and treated for 8 weeks in a double-blind manner. Total serum IgE, eosinophilic cation protein (ECP), eotaxin, thymus, and activation-regulated chemokine (TARC), IL-4, IL-5, and IL-13 levels were measured. Eosinophil counts were determined before and after treatment, and results were compared. In addition, possible adverse reactions were thoroughly checked in this first human trial. Results: Levels of total IgE significantly increased in the control group but showed no change in the PG102 group, and change differences between the control and PG102 groups were significant (+12.9%, vs.−5.7%, p = 0.015). Levels of ECP and eotaxin and eosinophil counts produced similar results. However, the other variables showed no significant changes after treatment. Conclusion: In this exploratory clinical trial, it was found that 8 weeks of treatment with PG102 effectively reduced the levels of total IgE in apparently asymptomatic subjects with atopy.
- Subjects
SOUTH Korea; ALLERGY prevention; ANALYSIS of variance; BIOPHYSICS; CHI-squared test; CLINICAL drug trials; FISHER exact test; IMMUNOGLOBULINS; KIWIFRUIT; RESEARCH methodology; MEDICAL cooperation; MEDICINAL plants; RESEARCH; RESEARCH funding; STATISTICAL sampling; STATISTICAL hypothesis testing; STATISTICS; T-test (Statistics); PLANT extracts; PILOT projects; STATISTICAL power analysis; DATA analysis; STATISTICAL significance; PRE-tests &; post-tests; BLIND experiment; DATA analysis software; CHEMICAL inhibitors
- Publication
European Journal of Nutrition, 2011, Vol 50, Issue 7, p523
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-010-0159-y