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- Title
Carvedilol, a New Beta-Adrenoreceptor Blocker Antihypertensive Drug, Protects against Free-Radical-Induced Endothelial Dysfunction.
- Authors
Lopez, Bernard L.; Christopher, Theodore A.; Yue, Tian-Li; Ruffolo, Robert; Feuerstein, Giora Z.; Ma, Xin-Liang
- Abstract
We tested the ability of carvedilol, an antihypertensive β-adrenoreceptor antagonist with antioxidant properties, to protect rat aorta rings from free-radical-induced endothelial cell (EC) dysfunction. Rings were exposed to the superoxide generator pyrogallol. Vascular function of intact rings was assessed by observing acetylcholine (ACh)-induced vasorelaxation following submaximal contraction by U-46619. Function of rings denuded of ECs was assessed by observing S-nitroso-N-acetylpenicillamine (SNAP)-induced vasorelaxation following submaximal contraction by U-46619. Carvedilol exerted a significant protective effect against pyrogallol-induced vasoconstriction (17.1 ± 4.8 vs. 31.9 ± 5.4% for vehicle, p < 0.05). Carvedilol also demonstrated significant protection against pyrogallol-induced endothelium dysfunction, enhancing vasorelaxation to 1,000 nmol/l ACh (73 ± 3.9 vs. 48 ± 3.0% vehicle, p < 0.01). These protective effects were not seen with propanolol, a pure β-receptor antagonist. Carvedilol mixed with pyrogallol and SNAP preserved SNAP-induced vasorelaxation in rings denuded of ECs (80.4 ± 5.3 vs. 63.7 ± 4.8% control, p < 0.05). Carvedilol appears to protect vascular function by scavenging free radicals and enhancing the effects of NO. Copyright © 1995 S. Karger AG, Basel
- Publication
Pharmacology, 1995, Vol 51, Issue 3, p165
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000139331