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- Title
Gemcitabine plus Paclitaxel as First-Line Chemotherapy for Patients with Advanced Breast Cancer.
- Authors
Delfino, Carlos; Caccia, Graciela; Gonzáles, Luis Riva; Mickiewicz, Elizabeth; Rodger, Jeannette; Balbiani, Luis; Morales, Daniel Flores; Comba, Alberto Zori; Brosio, Celia
- Abstract
Objectives: To assess the efficacy and tolerability of gemcitabine and paclitaxel as first-line treatment in advanced breast cancer. Methods: Patients with histologically confirmed metastatic or metastatic plus locally advanced breast cancer received gemcitabine 1,200 mg/m[sup 2] on days 1 and 8 and paclitaxel 175 mg/m[sup 2] on day 1 every 21 days for 8 cycles. Results: From December 1999 to August 2001, 45 patients, with a median age of 53.5 years (range, 22–77), received a total of 260 cycles. All were assessable for response and toxicity. Twenty-seven patients had prior adjuvant therapy. Hormonal receptor status was positive in 31.1% and negative in 40.0% of patients. Main metastatic sites included soft tissue (62.2%) and lung (53.3%). The objective response rate was 66.7%; complete response, 22.2%; partial response, 44.4%; stable disease, 15.6%; progressive disease, 17.8%. Median duration of response was 18 months and median time to tumor progression was 11 months. Grade 3/4 leukopenia, neutropenia, and thrombocytopenia developed in 13.3% of patients, and 15.5% developed grade 3/4 mucositis. No treatment-related deaths occurred. Median overall survival was 19 months. Conclusion: Gemcitabine plus paclitaxel is an active combination with a favorable toxicity profile as first-line treatment for patients with advanced breast cancer. Copyright © 2004 S. Karger AG, Basel
- Subjects
BREAST cancer; COMBINATION drug therapy; DRUG therapy; PACLITAXEL; METASTASIS
- Publication
Oncology, 2004, Vol 66, Issue 1, p18
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000076330