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- Title
Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage.
- Authors
Tempfer, Clemens; Unfried, Gertrud; Zeillinger, Robert; Hefler, Lukas; Nagele, Fritz; Huber, Johannes C.; Tempfer, C; Unfried, G; Zeillinger, R; Hefler, L; Nagele, F; Huber, J C
- Abstract
<bold>Background: </bold>Lack of endothelium-derived nitric oxide is associated with vasospasm and vascular infarction. We investigated the relationship between idiopathic recurrent miscarriage and a polymorphism of the gene encoding endothelial nitric oxide synthase (NOS3).<bold>Method: </bold>In a prospective case-control study, 105 women with idiopathic recurrent miscarriage and 91 healthy controls were investigated. We used the polymerase chain reaction to identify the different alleles of a 27 base pair tandem repeat polymorphism in intron 4 of the NOS3 gene.<bold>Results: </bold>The wild type B allele was identified on 329 out of 392 chromosomes (frequency 0.84). The polymorphic A allele was present on 63 chromosomes (frequency 0.16). The genotype frequencies were as follows: 68% (B/B), 31% (A/B) and.5% (A/A). The distribution of genotype frequencies was significantly different between the study and control groups for allele A/B heterozygotes (NOS3(A/B)) (36.7 versus 23.8%, P = 0.03, OR 1.6, 95% CI 1.1--3.8). Only one individual was homozygous for the A allele (NOS3(A/A)). She was in the study group. Between women with primary and secondary recurrent miscarriages, no statistically significant difference between the distribution of NOS3(A/B) genotypes (28 versus 34%) was observed.<bold>Conclusions: </bold>These data support a role for the NOS3 gene as a genetic determinant of the risk of idiopathic recurrent miscarriage.
- Publication
Human Reproduction, 2001, Vol 16, Issue 8, p1644
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/16.8.1644