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- Title
An integrative model of regulation centered on recognition of TCR peptide/MHC complexes.
- Authors
Kumar, Vipin; Sercarz, Eli
- Abstract
We have described a T-cell receptor (TCR)-centered model of immune regulation, in which MHC/TCR peptide complexes provide for the activation of regulatory T cells and likewise act as their target structures. In this model, the disease-causing effectors are TCR VΒ8.2 chain, in the appropriate MHC context. We have characterized the dominance, the dynamics as well as the TCR usage of both effector and regulatory T cells. We have begun to characterize the essential elements of the regulatory T-cell populations. Principles learned in this model have important implications for immune regulation in general.
- Subjects
T cells; IMMUNE system
- Publication
Immunological Reviews, 2001, Vol 182, Issue 1, p113
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1034/j.1600-065x.2001.1820109.x