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- Title
Concealed for a Long Time on the Marches of Empires: Hepatitis B Virus Genotype I.
- Authors
Marchio, Agnès; Sitbounlang, Philavanh; Deharo, Eric; Paboriboune, Phimpha; Pineau, Pascal
- Abstract
Genotype I, the penultimate HBV genotype to date, was granted the status of a bona fide genotype only in the XXIst century after some hesitations. The reason for these hesitations was that genotype I is a complex recombinant virus formed with segments from three original genotypes, A, C, and G. It was estimated that genotype I is responsible for only an infinitesimal fraction (<1.0%) of the chronic HBV infection burden worldwide. Furthermore, most probably due to its recent discovery and rarity, the natural history of infection with genotype I is poorly known in comparison with those of genotypes B or C that predominate in their area of circulation. Overall, genotype I is a minor genotype infecting ethnic minorities. It is endemic to the Southeast Asian Massif or Eastern Zomia, a vast mountainous or hilly region of 2.5 million km2 spreading from Eastern India to China, inhabited by a little more than 100 million persons belonging primarily to ethnic minorities speaking various types of languages (Tibeto-Burman, Austroasiatic, and Tai-Kadai) who managed to escape the authority of central states during historical times. Genotype I consists of two subtypes: I1, present in China, Laos, Thailand, and Vietnam; and I2, encountered in India, Laos, and Vietnam.
- Subjects
LAOS; VIETNAM; GENOTYPES; HEPATITIS B virus; HEPATITIS B; RECOMBINANT viruses; STATE power
- Publication
Microorganisms, 2023, Vol 11, Issue 9, p2204
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms11092204