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- Title
An assessment of minocycline sensitivity in multidrug-resistant gram-negative isolates in a tertiary care center of Western Maharashtra.
- Authors
Waje, Janhavi Sandip; Das, Nikunja Kumar; Mirza, Shahzad; Gandham, Nageswari; Vyawahare, Chanda; Khan, Sameena; Mukhida, Sahjid; Patil, Rajashri
- Abstract
Introduction: Infections caused by multidrug-resistant (MDR) gram-negative bacteria (GNB) have increased rapidly in recent years in all parts of the globe. The widespread use of antimicrobial medications to treat infections has resulted in the establishment of resistance among many microorganism strains. Minocycline can be used to treat infections of the skin, urinary and respiratory tracts, and genital system. This study was conducted to assess the sensitivity of minocycline in MDR GNB. Materials and Methods: A cross-sectional study was conducted for 4 months at a tertiary care hospital. All samples received in the microbiology laboratory were considered for the study. Clinically significant MDR GNB isolated from various samples are included in the study. Results: During the study period, 64 specimens were analyzed in the microbiology department. Of the total sample size, 67% of the isolates are sensitive to minocycline, 28% were resistant, and the remaining 5% showed intermediate results. Organisms belonging to the Acinetobacter baumannii complex were 42.85% sensitive, while all MDR Escherichia coli (E. coli), Klebsiella pneumoniae, and Myroides species are susceptible to minocycline. Conclusion: Minocycline is a broad-spectrum antibiotic that can be considered to be used to treat MDR GNB. Minocycline's usage in such bacterial infections has been limited due to the negative effects associated with systemic dosing. These results imply that minocycline could be used as a therapeutic agent for treating MDR infections that are difficult to treat with other antibiotics.
- Subjects
MAHARASHTRA (India); GRAM-negative bacteria; MINOCYCLINE; ESCHERICHIA coli; TERTIARY care; GENITALIA
- Publication
Journal of Dr. NTR University of Health Sciences, 2023, Vol 12, Issue 3, p261
- ISSN
2278-1889
- Publication type
Article
- DOI
10.4103/jdrysruhs.jdrysruhs_146_22