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- Title
No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves’ disease.
- Authors
Jennings, Claire E.; Owen, Catherine J.; Wilson, Valerie; Pearce, Simon H. S.
- Abstract
A functional polymorphism at codon 55 of the small ubiquitin-like modifier-4 (SUMO4) gene (methionine to valine; M55V) has recently been associated with type 1 diabetes mellitus (T1D). We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves’ disease (GD) and autoimmune Addison's disease.A case–control analysis was performed using genomic DNA samples from 595 unrelated white GD subjects, 104 white autoimmune Addison's disease subjects and 467 healthy white control subjects. TheSUMO4M55V single nucleotide polymorphism (SNP) was genotyped using polymerase chain reaction (PCR) amplification followed by digestion with the restriction enzymeMseI.There was no association of theSUMO4M55V alleles with either GD, thyroid-associated orbitopathy or autoimmune Addison's disease when compared to controls;P = 0·28, 0·46 and 0·91, respectively, byχ2 testing.We cannot confirm a generalized role for SUMO4 in autoimmune endocrinopathy. TheSUMO4codon 55 methionine to valine polymorphism may be exclusively associated with susceptibility to T1D, or the effect of the locus in GD and Addison's disease may be much less than that found in T1D patients.
- Subjects
GRAVES' disease; HYPERTHYROIDISM; AUTOIMMUNE diseases; DIABETES; METHIONINE; VALINE; GENETIC polymorphisms; POLYMERASE chain reaction
- Publication
Clinical Endocrinology, 2005, Vol 62, Issue 3, p362
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/j.1365-2265.2005.02224.x