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- Title
Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?
- Authors
Lawrence, Peter A.; Struhl, Gary; Casal, José
- Abstract
Most, perhaps all cells in epithelial sheets are polarized in the plane of the sheet. This type of polarity, referred to as planar cell polarity (PCP), can be expressed in the orientation of cilia and stereocilia, in oriented outgrowths such as hairs, in the plane of cell division, in directed cell movement and possibly in the orientation of axon extension. Another popular area in current research is growth: there is an attempt to find systems that fix the shape and size of organs. Although both polarity and growth are subject to overall control by morphogen gradients, the mechanisms of this control are almost completely unknown. Here we discuss recent evidence for a 'steepness hypothesis' that links these two apparently disconnected features of animal development.
- Subjects
CELL division; CELL proliferation; EPITHELIAL cells; CELL motility; MORPHOGENESIS
- Publication
Nature Cell Biology, 2008, Vol 10, Issue 12, p1379
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1208-1379