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- Title
The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.
- Authors
Accardi, Rosita; Gruffat, Henri; Sirand, Cécilia; Fusil, Floriane; Gheit, Tarik; Hernandez-Vargas, Hector; Le Calvez-Kelm, Florence; Traverse-Glehen, Alexandra; Cosset, François-Loïc; Manet, Evelyne; Wild, Christopher P.; Massimo Tommasino
- Abstract
Although Epstein-Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt's lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). Here, we show that exposure to AFB1 in in vitro and in vivo models induces activation of the EBV lytic cycle and increases EBV load, two events that are associated with an increased risk of eBL in vivo. AFB1 treatment leads to the alteration of cellular gene expression, with consequent activations of signaling pathways, e.g. PI3K, that in turn mediate reactivation of the EBV life cycle. Finally, we show that AFB1 triggers EBV-driven cellular transformation both in primary human B cells and in a humanized animal model. In summary, our data provide evidence for a role of AFB1 as a cofactor in EBV-mediated carcinogenesis.
- Subjects
SUB-Saharan Africa; MYCOTOXINS; EPSTEIN-Barr virus diseases; B cells; GENE expression; CARCINOGENESIS; IN vitro studies; ANIMAL models in research
- Publication
Carcinogenesis, 2015, Vol 36, Issue 11, p1440
- ISSN
0143-3334
- Publication type
Article
- DOI
10.1093/carcin/bgv142