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- Title
Association between triglyceride glucose-body mass index and heart failure in subjects with diabetes mellitus or prediabetes mellitus: a cross-sectional study.
- Authors
Shuping Yang; Xiangxiang Shi; Wanlu Liu; Zhaokai Wang; Ruoshui Li; Xianzhi Xu; Chaofan Wang; Lei Li; Ruili Wang; Tongda Xu
- Abstract
Background: The triglyceride glucose-body mass index (TyG-BMI) is a surrogate indicator of insulin resistance. However, the association of TyG-BMI with heart failure (HF) in individuals with diabetes mellitus or prediabetes mellitus is unknown. Methods: This study included 7,472 participants aged 20-80 years old with prediabetes or diabetes from the National Health and Nutrition Examination Survey (2007-2018). The TyG-BMI was calculated as Ln [triglyceride (mg/dL) x fasting blood glucose (mg/dL)/2] x BMI, and individuals were categorized into tertiles based on TyG-BMI levels. The relationship of TyG-BMI with HF was analyzed using multiple logistic regression models. Subgroup analyses were stratified by gender, age, hypertension, and diabetes mellitus status. Results: This cross-sectional study had 7,472 participants (weighted n = 111,808,357), including 329 HF participants. Participants with a high TyG-BMI were prone to HF. The highest tertile group with a fully adjusted model was more likely to have HF compared to the lowest tertile group (odds ratio [OR], 2.645; 95% CI, 1.529-4.576). Restricted cubic spline analysis showed a significant dose- response relationship between TyG-BMI and HF (P < 0.001). In subgroup analyses, similar results were seen in terms of age (≥50 years old), gender, hypertension, and diabetes mellitus status. Conclusion: A high TyG-BMI is significantly associated with HF risk in participants with diabetes mellitus or prediabetes mellitus.
- Subjects
DIABETES; PREDIABETIC state; HEART failure; HEALTH &; Nutrition Examination Survey; CROSS-sectional method; BLOOD sugar; TRIGLYCERIDES
- Publication
Frontiers in Endocrinology, 2023, p01
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2023.1294909