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- Title
Dilinoleoylphosphatidylcholine induces the expression of the anti-inflammatory heme oxygenase-1 in RAW264.7 macrophages.
- Authors
Yong Son; Ju Hwan Lee; Nam-Ho Kim; Na-Young Surh; Eun-Cheol Kim; Hun-Taeg Chung; Dae Gill Kang; Hyun-Ock Pae
- Abstract
1,2-Dilinoleoyl-sn-glycero-3-phosphocholine (DLPC), the main and active component of soybean lecithin, has been reported to exert anti-inflammatory effects, but the underlying mechanisms remain to be established. It was found that DLPC could induce the expression of the anti-inflammatory heme oxygenase-1 (HO-1) through the activation of nuclear erythroid 2-related factor 2 (Nrf2) in RAW264.7 macrophages. Pretreatment with DLPC suppressed the expression of inducible nitric oxide (NO) synthase (iNOS), one of proinflammatory enzymes, and reduced NO production in lipopolysaccharide (LPS)-stimulated macrophages. Similarly, DLPC also diminished the production of tumor necrosis factor-α (TNF-α), one of proinflammatory cytokines. Interestingly, the inhibitory effects of DLPC on LPS-induced iNOS expression and TNF-α production were reversed by tin protoporphyrin, a HO-1 inhibitor. Thus, HO-1 expression via Nrf2 activation may be one of the possible mechanisms explaining the anti-inflammatory effects of DLPC.
- Subjects
LECITHIN; SOYBEAN; MACROPHAGES; OXYGENASES; ERYTHROCYTE membranes; ENDOTOXINS
- Publication
Biofactors, 2010, Vol 36, Issue 3, p210
- ISSN
0951-6433
- Publication type
Article
- DOI
10.1002/biof.87