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- Title
Synthesis, characterization and antitumor activity of the germanium-quercetin complex.
- Authors
Zhai, Guangyu; Zhu, Wei; Duan, Yandan; Qu, Wentao; Yan, Zitong
- Abstract
Quercetin-germanium (Ge) (IV) complex was synthesized in the laboratory. The structure and physicochemical properties of the complex were characterized utilizing thermal and spectroscopic (UV-vis, IR and 1H NMR) analysis. The antitumor activity of quercetin-Ge (IV) compound was evaluated by the MTT method. The complex was subjected to biological tests in vitro using four tumor cell lines (PC-3, Hela, EC9706 and SPC-A-1). The quercetin-Ge (IV) complex showed significant cytotoxicity against four tumor cell lines.
- Subjects
GERMANIUM; QUERCETIN; THERMAL analysis; CELL lines; FLAVONOIDS; SPECTRUM analysis
- Publication
Main Group Metal Chemistry, 2012, Vol 35, Issue 3/4, p103
- ISSN
0792-1241
- Publication type
Article
- DOI
10.1515/mgmc-2012-0026