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- Title
Neuro-imunitné interakcie organizmu v onkogenenéze mnohopočetného myelómu a ich terapeutické využitie.
- Authors
P., Kotouček; R., Enright; A., Orfao; J., Sedlák
- Abstract
Multiple myeloma is a malignancy originating from the immune system and the second most prevalent blood cancer. Myeloma cells derive from the process of somatic hypermutation in the post-germinal centre of lymph nodes. They migrate from the post-germinal centre to the bone marrow compartment where they completely suppress healthy hematopoietic stem cells. They settle in the haemopoietic stem cell niche by a specific process called "homing" taking control over all supportive stromal cells including the cells of the immune system, neurons and Schwann cells of the vegetative nervous system. Neurons of the sympathetic nervous systems end in the centre of each niche. Myeloma cells are fully supported by all these stromal cells in their proliferation and growth. We describe in this article the interactions between the neuro-immune system of the human body and the myeloma malignant plasma cells. Stromal neuro-immune cells stimulate the growth and proliferation of myeloma cells and new therapeutic interventions could reverse these interactions thus restoring the original immune surveillance in order to control myeloma. We describe the principles of immuno-chemotherapy in myeloma and its reinforcement using new interventions targeting these neuro-immune interactions.
- Publication
Transfusiology & Haematology Today / Transfuze a Hematologie Dnes, 2021, Vol 27, Issue 4, p306
- ISSN
1213-5763
- Publication type
Article
- DOI
10.48095/cctahd2021306