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- Title
Role of platelets and von Willebrand factor in pro-coagulant state in inflammatory bowel disease.
- Authors
Schellenberg, Célia; Regnault, Véronique; Denis, Cécile; Lenting, Peter; Patrick, Lacolley; Peyrin-Biroulet, Laurent; Lagrange, Jeremy
- Abstract
Introduction: Inflammatory bowel disease (IBD) represents an independent risk factor for thrombosis. However, the causes of this increased risk of thrombosis are still elusive. Objectives: We aim to decipher the main players in the procoagulant phenotype associated with IBD.Methods and Results: Coagulation phenotype assessment was performed in IBD patients included in the "I-BANK project" (CHRU Nancy), a prospective monocentric study recruiting 1000 IBD patients and in a mouse model of IBD (dextran sulphate sodium: DSS). We found an increase in platelet count in active IBD patients and an increased thrombin generation (TG) in platelet-rich plasma. Similar results were obtained in mice treated with DSS. In platelet-poor plasma, TG was not increased, highlighting the role of platelets in this phenotype. In addition, both mice and active patients showed platelet agglutination on blood smears. As circulating von Willebrand factor (VWF), which has a procoagulant function and may be involved in platelet agglutination, is elevated in IBD patients, we used VWF-deficient mice. In these mice, TG in platelet-rich plasma was not increased in response to DSS treatment. In contrast, VWF-deficient mice receiving DSS showed worsened colonic tissue damage, highlighting the importance of maintaining a normal coagulation balance in IBD. Conclusion: The procoagulant phenotype in IBD depends on platelet agglutination via VWF. Further studies are needed to assess the possible beneficial effect of VWF inhibition in IBD patients at high risk of thrombosis without aggravating tissue damage.
- Subjects
INFLAMMATORY bowel diseases; THROMBOSIS
- Publication
Artery Research, 2023, Vol 29, Issue 1, pS41
- ISSN
1872-9312
- Publication type
Article
- DOI
10.1007/s44200-022-00028-8