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- Title
Association Analysis of IGF2BP2, KCNJ11, and CDKAL1 Polymorphisms with Type 2 Diabetes Mellitus in a Moroccan Population: A Case-Control Study and Meta-analysis.
- Authors
Benrahma, Houda; Charoute, Hicham; Lasram, Khaled; Boulouiz, Redouane; Atig, Rym; Fakiri, Malika; Rouba, Hassan; Abdelhak, Sonia; Barakat, Abdelhamid
- Abstract
Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
- Subjects
INSULIN-like growth factor-binding proteins; POTASSIUM channels; CYCLIN-dependent kinases; GENETICS of type 2 diabetes; GENETIC polymorphisms; MOROCCANS; DISEASES
- Publication
Biochemical Genetics, 2014, Vol 52, Issue 9/10, p430
- ISSN
0006-2928
- Publication type
Article
- DOI
10.1007/s10528-014-9658-5