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- Title
Pre-eclampsia with the nephrotic syndrome.
- Authors
First, M. Roy; Ooi, Boon S.; Jao, Wellington; Pollak, Victor E.
- Abstract
Heavy proteinuria and/or the nephritic syndrome rarely occur late in pregnancy. We report the clinical and renal biopsy findings on 11 patients with the nephritic syndrome occurring during pregnancy in whom light and electron microscopic findings were characteristic of pr-eclampsia. Immunofluorescent microscopy revealed deposits of IgG, IgM, IgA, β1C globulin, and fibrinogenm predominantly in the subendothelial position. Only two patients were primigravid; three were in their second or third pregnancy; in six, pre-eclampsa first occurred in the fourth to eight pregnancy. Clinical abnormalities appeared first between the 23rd and 39th week of gestation. All patients had marked elevation of blood pressure and of serum uric acid levels. Of the 12 infants, eight were alive and well, including one set of twins; four were stillborn. Following delivery, clinical resolution was similar to that in less severe pre-eclampsia. The findings suggest the possible importance of the role of intravascular coagulation in the genesis of pre-eclampsia.
- Subjects
PROTEINURIA; NEPHROTIC syndrome; PREECLAMPSIA; INFANT diseases
- Publication
Kidney International, 1978, Vol 13, Issue 2, p166
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1978.24